Androgen Deprivation Therapy and Mental Health: Impact on Depression and Cognition

Journal article Abstract: European Urology Focus Volume 6 Issue 6 2020

DOI: 10.1016/j.euf.2019.11.010

“Androgen deprivation therapy (ADT) is a common treatment for many men with prostate cancer. Use of ADT can have significant impacts on the mental health of patients with both localized and advanced disease. Prostate cancer patients receiving ADT have a 41% higher risk of depression and a 47% higher risk of dementia. Risk factors for the development of depression in this group of men include older age, marital status, greater comorbidity, and a previous history of depression, while being retired may offer a protective effect. Optimal treatment strategies for depression for these men are not well established in the literature.”

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